Senior Clinical Research Associate

Senior Clinical Research Associate (SCRA) – Oncology | Brazil | Permanent

Upsilon Global is supporting the growth of an established international medical-device organisation with an expanding clinical research portfolio and a strong focus on Oncology & Rare Disease.

We are seeking an experienced Senior Clinical Research Associate (SCRA) to join a well-rounded, collaborative clinical operations team in Brazil, supporting the delivery of clinical studies across Brazil and internationally.

This opportunity is suited to an experienced clinical research professional who can independently oversee clinical trial sites, maintain high standards of data quality and regulatory compliance, and work closely with international study teams. The role offers the opportunity to contribute to Oncology & Rare Disease-focused clinical research while taking ownership of monitoring activities within a growing medical-device organisation.

Working alongside experienced clinical research professionals and cross-functional stakeholders, the successful candidate will play an important role in driving site performance, identifying and mitigating study risks, and supporting the successful delivery of clinical trials throughout the study lifecycle.

POSITION DETAILS

Position: Senior Clinical Research Associate (SCRA)

Therapeutic Focus: Oncology & Rare Disease

Location: Brazil

Contract: Permanent

Start Date: To be confirmed

Experience: Strong independent clinical trial monitoring experience

Languages: Portuguese and English

Travel: Regular travel within Brazil, with occasional international travel

ABOUT THE OPPORTUNITY:

The organisation combines scientific expertise, clinical innovation and strong operational delivery, with an emphasis on collaboration across international clinical research teams.

With a strong focus on Oncology & Rare Disease, this position offers the opportunity to contribute to clinical studies within a specialised therapeutic area while working alongside a well-rounded team of clinical research professionals. The SCRA will take responsibility for site oversight, monitoring quality and compliance, ensuring that clinical trial activities are conducted in accordance with study protocols, applicable regulations and ICH-GCP requirements.

The role encompasses the full clinical trial lifecycle, from study start-up through to close-out, with close engagement with investigators, site staff, sponsors and internal clinical operations teams.

For a Senior CRA seeking greater ownership, broader project exposure and the opportunity to contribute to clinical research within an international medical-device environment, this position offers a compelling next step.

KEY REQUIREMENTS:

• Strong experience working as a Clinical Research Associate, with demonstrated capability at Senior CRA level.
• Proven experience conducting independent clinical trial monitoring visits.
• Experience with interventional clinical trials, ideally within Oncology & Rare Disease.
• Strong knowledge of ICH-GCP, applicable clinical trial regulations and monitoring practices.
• Experience across the clinical trial lifecycle, from study start-up through to close-out.
• Experience conducting Site Selection Visits, Site Initiation Visits, Interim Monitoring Visits and Close-Out Visits.
• Strong understanding of Source Data Verification (SDV) and Source Data Review (SDR).
• Experience managing site relationships and working with investigators, study coordinators and clinical trial sites.
• Ability to identify, assess and follow up on site-level risks, protocol deviations and compliance issues.
• Strong organisational, time-management and problem-solving skills.
• Excellent attention to detail and a commitment to clinical quality and patient safety.
• Ability to manage monitoring responsibilities independently while contributing effectively to an international study team.
• Strong written and verbal communication skills in French and English.
• Willingness and ability to travel regularly within France, with occasional international travel.

KEY RESPONSIBILITIES:

The successful candidate will be responsible for:

• Independently conducting Site Selection Visits, Site Initiation Visits, Interim Monitoring Visits and Close-Out Visits.
• Monitoring clinical trial sites in accordance with study protocols, sponsor requirements, ICH-GCP and applicable regulations.
• Conducting Source Data Verification and Source Data Review to ensure data quality, accuracy and integrity.
• Reviewing informed consent documentation and supporting patient safety and participant protection.
• Identifying, documenting and following up on protocol deviations, site issues and study-related risks.
• Providing guidance to investigators and site staff regarding study requirements, procedures and compliance expectations.
• Maintaining effective communication with investigators, study coordinators, sponsors and internal clinical operations teams.
• Preparing accurate, high-quality mo